Calcium regulation of single ryanodine receptor channel gating analyzed using HMM/MCMC statistical methods.

ABSTRACT: Type-II ryanodine receptor channels (RYRs) play a fundamental role in intracellular Ca(2+) dynamics in heart. The processes of activation, inactivation, and regulation of these channels have been the subject of intensive research and the focus of recent debates. Typically, approaches to understand these processes involve statistical analysis of single RYRs, involving signal restoration, model estimation, and selection. These tasks are usually performed by following rather phenomenological criteria that turn models into self-fulfilling prophecies. Here, a thorough statistical treatment is applied by modeling single RYRs using aggregated hidden Markov models. Inferences are made using Bayesian statistics and stochastic search methods known as Markov chain Monte Carlo. These methods allow ext

SUBMITTER: Rosales RA 

PROVIDER: S-EPMC2234502 | biostudies-literature | 2004 May

REPOSITORIES: biostudies-literature