Conservation of transcriptional sensing systems in prokaryotes: a perspective from Escherichia coli.

ABSTRACT: The activity of transcription factors is usually governed by allosteric physicochemical signals or metabolites, which are in turn produced in the cell or obtained from the environment by the activity of the products of effector genes. Previously, we identified a collection of more than 110 transcription factors and their corresponding effector genes in Escherichia coli K-12. Here, we introduce the notion of "triferog", which relates to the identification of orthologous transcription factors and effector genes across genomes and show that transcriptional sensing systems known in E. coli are poorly conserved beyond Salmonella. We also find that enzymes that act as effector genes for the production of endogenous effector metabolites are more conserved than their corresponding effector genes e

SUBMITTER: Salgado H 

PROVIDER: S-EPMC2238691 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature