Assessing the evolutionary rate of positional orthologous genes in prokaryotes using synteny data.

ABSTRACT:

Background

Comparison of completely sequenced microbial genomes has revealed how fluid these genomes are. Detecting synteny blocks requires reliable methods to determining the orthologs among the whole set of homologs detected by exhaustive comparisons between each pair of completely sequenced genomes. This is a complex and difficult problem in the field of comparative genomics but will help to better understand the way prokaryotic genomes are evolving.

Results

We have developed a suite of programs that automate three essential steps to study conservation of gene order, and validated them with a set of 107 bacteria and archaea that cover the majority of the prokaryotic taxonomic space. We identified the whole set of shared homologs between two or more species and computed th

SUBMITTER: Lemoine F 

PROVIDER: S-EPMC2238764 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature