Towards a pathway definition of Parkinson's disease: a complex disorder with links to cancer, diabetes and inflammation.

ABSTRACT: We have previously established a first whole genome transcriptomic profile of sporadic Parkinson's disease (PD). After extensive brain tissue-based validation combined with cycles of iterative data analysis and by focusing on the most comparable cases of the cohort, we have refined our analysis and established a list of 892 highly dysregulated priority genes that are considered to form the core of the diseased Parkinsonian metabolic network. The substantia nigra pathways, now under scrutiny, contain more than 100 genes whose association with PD is known from the literature. Of those, more than 40 genes belong to the highly significantly dysregulated group identified in our dataset. Apart from the complete list of 892 priority genes, we present pathways revealing PD 'hub' as well as 'periph

SUBMITTER: Moran LB 

PROVIDER: S-EPMC2238789 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature