Human PAML browser: a database of positive selection on human genes using phylogenetic methods.

ABSTRACT: With the recent increase in the number of mammalian genomes being sequenced, large-scale genome scans for human-specific positive selection are now possible. Selection can be inferred through phylogenetic analysis by comparing the rates of silent and replacement substitution between related species. Maximum-likelihood (ML) analysis of codon substitution models can be used to identify genes with an accelerated pattern of amino acid substitution on a particular lineage. However, the ML methods are computationally intensive and awkward to configure. We have created a database that contains the results of tests for positive selection along the human lineage in 13,721 genes with orthologs in the UCSC multispecies genome alignments. The Human PAML Browser is a resource through which researchers

SUBMITTER: Nickel GC 

PROVIDER: S-EPMC2238824 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature