SelenoDB 1.0 : a database of selenoprotein genes, proteins and SECIS elements.

ABSTRACT: Selenoproteins are a diverse group of proteins usually misidentified and misannotated in sequence databases. The presence of an in-frame UGA (stop) codon in the coding sequence of selenoprotein genes precludes their identification and correct annotation. The in-frame UGA codons are recoded to cotranslationally incorporate selenocysteine, a rare selenium-containing amino acid. The development of ad hoc experimental and, more recently, computational approaches have allowed the efficient identification and characterization of the selenoproteomes of a growing number of species. Today, dozens of selenoprotein families have been described and more are being discovered in recently sequenced species, but the correct genomic annotation is not available for the majority of these genes. SelenoDB is a

SUBMITTER: Castellano S 

PROVIDER: S-EPMC2238826 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature