ProSAS: a database for analyzing alternative splicing in the context of protein structures.

ABSTRACT: Alternative splicing is known to be one of the major sources for functional diversity in higher eukaryotes. Several splicing isoforms have been characterized in the literature that play important roles in cellular processes like apoptosis or signal transduction pathways. Splicing events can often be detected on the mRNA level by large-scale cDNA or EST experiments and such data is collected and annotated in several databases. Nevertheless, the effects of splicing on the structure of a protein are largely unknown. The ProSAS (Protein Structure and Alternative Splicing) database fills this gap and provides a unified resource for analyzing effects of alternative splicing events in the context of protein structures. ProSAS comprehensively annotates and models protein structures for several Ens

SUBMITTER: Birzele F 

PROVIDER: S-EPMC2238869 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature