Synthesis of (-)-Indolizidine 167B based on domino hydroformylation/cyclization reactions.

ABSTRACT: The synthesis of (-)-Indolizidine 167B has been achieved from optically active (R)-3-(pyrrol-1-yl)hex-1-ene. The key step is a highly regioselective hydroformylation reaction and a one-pot intramolecular cyclization providing a general approach to the indolizine nucleus.

SUBMITTER: Guazzelli G 

PROVIDER: S-EPMC2241606 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature