Genome-wide changes in expression profile of murine endogenous retroviruses (MuERVs) in distant organs after burn injury.

ABSTRACT:

Background

Previous studies have shown that burn-elicited stress signals alter expression of certain murine endogenous retroviruses (MuERVs) in distant organs of mice. These findings suggest that MuERVs may participate in a network of pathophysiologic events during post-burn systemic response. To gain a better understanding of the biological roles of MuERVs in post-burn systemic response, we examined the genome-wide changes in the MuERV expression profiles in distant organs and the biological properties of the putative-burn related MuERVs were characterized.

Results

Female C57BL/6J mice were subjected to an approximately 18 % total body surface area flame burn and tissues (liver, lung, and kidney) were harvested at 3 hours and 24 hours after injury. The changes in the MuERV

SUBMITTER: Lee YK 

PROVIDER: S-EPMC2241634 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature