Human VRK1 is an early response gene and its loss causes a block in cell cycle progression.

ABSTRACT:

Background

In mammalian cells regulatory proteins controlling the cell cycle are necessary due to the requirements of living in a heterogeneous environment of cell-interactions and growth factors. VRK1 is a novel serine-threonine kinase that phosphorylates several transcription factors and is associated with proliferation phenotypes.

Methodology/principal findings

In this report VRK1 has been identified as regulated in the cell cycle. VRK1 gene expression is activated by the addition of serum to starved cells, indicating it is required for the exit of G0 phase and entry in G1; a response that parallels the re-expression of MYC, FOS and CCND1 (cyclin D1) genes, suggesting that VRK1 is an early-response gene. VRK1 gene expression is also shutdown by serum withdrawal. The human

SUBMITTER: Valbuena A 

PROVIDER: S-EPMC2241669 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature