Gene Ontology annotation quality analysis in model eukaryotes.

ABSTRACT: Functional analysis using the Gene Ontology (GO) is crucial for array analysis, but it is often difficult for researchers to assess the amount and quality of GO annotations associated with different sets of gene products. In many cases the source of the GO annotations and the date the GO annotations were last updated is not apparent, further complicating a researchers' ability to assess the quality of the GO data provided. Moreover, GO biocurators need to ensure that the GO quality is maintained and optimal for the functional processes that are most relevant for their research community. We report the GO Annotation Quality (GAQ) score, a quantitative measure of GO quality that includes breadth of GO annotation, the level of detail of annotation and the type of evidence used to make the ann

SUBMITTER: Buza TJ 

PROVIDER: S-EPMC2241866 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature