Developmentally regulated cleavage of tRNAs in the bacterium Streptomyces coelicolor.

ABSTRACT: The ability to sense and respond to environmental and physiological signals is critical for the survival of the soil-dwelling Gram-positive bacterium Streptomyces coelicolor. Nutrient deprivation triggers the onset of a complex morphological differentiation process that involves the raising of aerial hyphae and formation of spore chains, and coincides with the production of a diverse array of clinically relevant antibiotics and other secondary metabolites. These processes are tightly regulated; however, the genes and signals involved have not been fully elucidated. Here, we report a novel tRNA cleavage event that follows the same temporal regulation as morphological and physiological differentiation, and is growth medium dependent. All tRNAs appear to be susceptible to cleavage; however, t

SUBMITTER: Haiser HJ 

PROVIDER: S-EPMC2241913 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature