Transplanted endothelial cells repopulate the liver endothelium and correct the phenotype of hemophilia A mice.

ABSTRACT: Transplantation of healthy cells to repair organ damage or replace deficient functions constitutes a major goal of cell therapy. However, the mechanisms by which transplanted cells engraft, proliferate, and function remain unknown. To investigate whether host liver sinusoidal endothelium could be replaced with transplanted liver sinusoidal endothelial cells, we developed an animal model of tissue replacement that utilized a genetic system to identify transplanted cells and induced host-cell perturbations to confer a proliferative advantage to transplanted cells. Under these experimental conditions, transplanted cells engrafted efficiently and proliferated to replace substantial portions of the liver endothelium. Tissue studies demonstrated that transplanted cells became integral to the liv

SUBMITTER: Follenzi A 

PROVIDER: S-EPMC2242617 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature