Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomas.

ABSTRACT:

Introduction

Breast cancer is a heterogeneous group of tumors, and can be subdivided on the basis of histopathological features, genetic alterations and gene-expression profiles. One well-defined subtype of breast cancer is characterized by a lack of HER2 gene amplification and estrogen and progesterone receptor expression ('triple-negative tumors'). We examined the histopathological and gene-expression profile of triple-negative tumors to define subgroups with specific characteristics, including risk of developing distant metastases.

Methods

97 triple-negative tumors were selected from the fresh-frozen tissue bank of the Netherlands Cancer Institute, and gene-expression profiles were generated using 35K oligonucleotide microarrays. In addition, histopathological and immunoh

SUBMITTER: Kreike B 

PROVIDER: S-EPMC2242660 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature