High-confidence prediction of global interactomes based on genome-wide coevolutionary networks.

ABSTRACT: Interacting or functionally related protein families tend to have similar phylogenetic trees. Based on this observation, techniques have been developed to predict interaction partners. The observed degree of similarity between the phylogenetic trees of two proteins is the result of many different factors besides the actual interaction or functional relationship between them. Such factors influence the performance of interaction predictions. One aspect that can influence this similarity is related to the fact that a given protein interacts with many others, and hence it must adapt to all of them. Accordingly, the interaction or coadaptation signal within its tree is a composite of the influence of all of the interactors. Here, we introduce a new estimator of coevolution to overcome this and

SUBMITTER: Juan D 

PROVIDER: S-EPMC2242690 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature