Functional evolution of the p53 regulatory network through its target response elements.

ABSTRACT: Transcriptional network evolution is central to the development of complex biological systems. Networks can evolve through variation of master regulators and/or by changes in regulation of genes within networks. To gain insight into meaningful evolutionary differences in large networks, it is essential to address the functional consequences of sequence differences in response elements (REs) targeted by transcription factors. Using a combination of custom bioinformatics and multispecies alignment of promoter regions, we investigated the functional evolution of REs in terms of responsiveness to the sequence-specific transcription factor p53, a tumor suppressor and master regulator of stress responses. We identified REs orthologous to known p53 targets in human and rodent cells or alternative

SUBMITTER: Jegga AG 

PROVIDER: S-EPMC2242714 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature