Mef2 activity levels differentially affect gene expression during Drosophila muscle development.

ABSTRACT: Cell differentiation is controlled by key transcription factors, and a major question is how they orchestrate cell-type-specific genetic programs. Muscle differentiation is a well studied paradigm in which the conserved Mef2 transcription factor plays a pivotal role. Recent genomic studies have identified a large number of mef2-regulated target genes with distinct temporal expression profiles during Drosophila myogenesis. However, the question remains as to how a single transcription factor can control such diverse patterns of gene expression. In this study we used a strategy combining genomics and developmental genetics to address this issue in vivo during Drosophila muscle development. We found that groups of mef2-regulated genes respond differently to changes in mef2 activity levels: so

SUBMITTER: Elgar SJ 

PROVIDER: S-EPMC2242723 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature