Analysis and prediction of protective continuous B-cell epitopes on pathogen proteins.

ABSTRACT:

Background

The application of peptide based diagnostics and therapeutics mimicking part of protein antigen is experiencing renewed interest. So far selection and design rationale for such peptides is usually driven by T-cell epitope prediction, available experimental and modelled 3D structure, B-cell epitope predictions such as hydrophilicity plots or experience. If no structure is available the rational selection of peptides for the production of functionally altering or neutralizing antibodies is practically impossible. Specifically if many alternative antigens are available the reduction of required synthesized peptides until one successful candidate is found is of central technical interest. We have investigated the integration of B-cell epitope prediction with the variability

SUBMITTER: Sollner J 

PROVIDER: S-EPMC2244602 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature