Codon-triplet context unveils unique features of the Candida albicans protein coding genome.

ABSTRACT:

Background

The evolutionary forces that determine the arrangement of synonymous codons within open reading frames and fine tune mRNA translation efficiency are not yet understood. In order to tackle this question we have carried out a large scale study of codon-triplet contexts in 11 fungal species to unravel associations or relationships between codons present at the ribosome A-, P- and E-sites during each decoding cycle.

Results

Our analysis unveiled high bias within the context of codon-triplets, in particular strong preference for triplets of identical codons. We have also identified a surprisingly large number of codon-triplet combinations that vanished from fungal ORFeomes. Candida albicans exacerbated these features, showed an unbalanced tRNA population for decoding i

SUBMITTER: Moura GR 

PROVIDER: S-EPMC2244636 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature