Gene expression trees in lymphoid development.

ABSTRACT:

Background

The regulatory processes that govern cell proliferation and differentiation are central to developmental biology. Particularly well studied in this respect is the lymphoid system due to its importance for basic biology and for clinical applications. Gene expression measured in lymphoid cells in several distinguishable developmental stages helps in the elucidation of underlying molecular processes, which change gradually over time and lock cells in either the B cell, T cell or Natural Killer cell lineages. Large-scale analysis of these gene expression trees requires computational support for tasks ranging from visualization, querying, and finding clusters of similar genes, to answering detailed questions about the functional roles of individual genes.

Results

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SUBMITTER: Costa IG 

PROVIDER: S-EPMC2244641 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature