The E3 ubiquitin ligase skp2 regulates neural differentiation independent from the cell cycle.

ABSTRACT:

Background

The SCFskp2 complex is an E3 ubiquitin ligase that is known to target a number of cell cycle regulators, including cyclin-dependent kinase inhibitors, for proteolysis. While its role in regulation of cell division has been well documented, additional functions in differentiation, including in the nervous system, have not been investigated.

Results

Using Xenopus as a model system, here we demonstrate that skp2 has an additional role in regulation of differentiation of primary neurons, the first neurons to differentiate in the neural plate. Xenopus skp2 shows a dynamic expression pattern in early embryonic neural tissue and depletion of skp2 results in generation of extra primary neurons. In contrast, over-expression of skp2 inhibits neurogenesis in a manner depende

SUBMITTER: Boix-Perales H 

PROVIDER: S-EPMC2244796 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature