Effect of synthetic dietary triglycerides: a novel research paradigm for nutrigenomics.

ABSTRACT:

Background

The effect of dietary fats on human health and disease are likely mediated by changes in gene expression. Several transcription factors have been shown to respond to fatty acids, including SREBP-1c, NF-kappaB, RXRs, LXRs, FXR, HNF4alpha, and PPARs. However, it is unclear to what extent these transcription factors play a role in gene regulation by dietary fatty acids in vivo.

Methodology/principal findings

Here, we take advantage of a unique experimental design using synthetic triglycerides composed of one single fatty acid in combination with gene expression profiling to examine the effects of various individual dietary fatty acids on hepatic gene expression in mice. We observed that the number of significantly changed genes and the fold-induction of genes increas

SUBMITTER: Sanderson LM 

PROVIDER: S-EPMC2244803 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature