Influenza A H5N1 immigration is filtered out at some international borders.

ABSTRACT:

Background

Geographic spread of highly pathogenic influenza A H5N1, the bird flu strain, appears a necessary condition for accelerating the evolution of a related human-to-human infection. As H5N1 spreads the virus diversifies in response to the variety of socioecological environments encountered, increasing the chance a human infection emerges. Genetic phylogenies have for the most part provided only qualitative evidence that localities differ in H5N1 diversity. For the first time H5N1 variation is quantified across geographic space.

Methodology and principal findings

We constructed a statistical phylogeography of 481 H5N1 hemagglutinin genetic sequences from samples collected across 28 Eurasian and African localities through 2006. The MigraPhyla protocol showed southern Ch

SUBMITTER: Wallace RG 

PROVIDER: S-EPMC2244808 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature