A novel method for high accuracy sumoylation site prediction from protein sequences.

ABSTRACT:

Background

Protein sumoylation is an essential dynamic, reversible post translational modification that plays a role in dozens of cellular activities, especially the regulation of gene expression and the maintenance of genomic stability. Currently, the complexities of sumoylation mechanism can not be perfectly solved by experimental approaches. In this regard, computational approaches might represent a promising method to direct experimental identification of sumoylation sites and shed light on the understanding of the reaction mechanism.

Results

Here we presented a statistical method for sumoylation site prediction. A 5-fold cross validation test over the experimentally identified sumoylation sites yielded excellent prediction performance with correlation coefficient, speci

SUBMITTER: Xu J 

PROVIDER: S-EPMC2245905 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature