Analysis of gene expression during neurite outgrowth and regeneration.

ABSTRACT:

Background

The ability of a neuron to regenerate functional connections after injury is influenced by both its intrinsic state and also by extrinsic cues in its surroundings. Investigations of the transcriptional changes undergone by neurons during in vivo models of injury and regeneration have revealed many transcripts associated with these processes. Because of the complex milieu of interactions in vivo, these results include not only expression changes directly related to regenerative outgrowth and but also unrelated responses to surrounding cells and signals. In vitro models of neurite outgrowth provide a means to study the intrinsic transcriptional patterns of neurite outgrowth in the absence of extensive extrinsic cues from nearby cells and tissues.

Results

We have und

SUBMITTER: Szpara ML 

PROVIDER: S-EPMC2245955 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature