Slow GABA(A) mediated synaptic transmission in rat visual cortex.

ABSTRACT:

Background

Previous reports of inhibition in the neocortex suggest that inhibition is mediated predominantly through GABA(A) receptors exhibiting fast kinetics. Within the hippocampus, it has been shown that GABA(A) responses can take the form of either fast or slow response kinetics. Our findings indicate, for the first time, that the neocortex displays synaptic responses with slow GABA(A) receptor mediated inhibitory postsynaptic currents (IPSCs). These IPSCs are kinetically and pharmacologically similar to responses found in the hippocampus, although the anatomical specificity of evoked responses is unique from hippocampus. Spontaneous slow GABA(A) IPSCs were recorded from both pyramidal and inhibitory neurons in rat visual cortex.

Results

GABA(A) slow IPSCs were signific

SUBMITTER: Sceniak MP 

PROVIDER: S-EPMC2245967 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature