Integration of global signaling pathways, cAMP-PKA, MAPK and TOR in the regulation of FLO11.

ABSTRACT: The budding yeast, Saccharomyces cerevisiae, responds to various environmental cues by invoking specific adaptive mechanisms for their survival. Under nitrogen limitation, S. cerevisiae undergoes a dimorphic filamentous transition called pseudohyphae, which helps the cell to forage for nutrients and reach an environment conducive for growth. This transition is governed by a complex network of signaling pathways, namely cAMP-PKA, MAPK and TOR, which controls the transcriptional activation of FLO11, a flocculin gene that encodes a cell wall protein. However, little is known about how these pathways co-ordinate to govern the conversion of nutritional availability into gene expression. Here, we have analyzed an integrative network comprised of cAMP-PKA, MAPK and TOR pathways with respect to th

SUBMITTER: Vinod PK 

PROVIDER: S-EPMC2246015 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature