Cerebellum morphogenesis: the foliation pattern is orchestrated by multi-cellular anchoring centers.

ABSTRACT:

Background

The cerebellum has a striking morphology consisting of folia separated by fissures of different lengths. Since folia in mammals likely serve as a broad platform on which the anterior-posterior organization of the sensory-motor circuits of the cerebellum are built, it is important to understand how such complex morphology arises.

Results

Using a combination of genetic inducible fate mapping, high-resolution cellular analysis and mutant studies in mouse, we demonstrate that a key event in initiation of foliation is the acquisition of a distinct cytoarchitecture in the regions that will become the base of each fissure. We term these regions 'anchoring centers'. We show that the first manifestation of anchoring centers when the cerebellar outer surface is smooth is an

SUBMITTER: Sudarov A 

PROVIDER: S-EPMC2246128 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature