All duplicates are not equal: the difference between small-scale and genome duplication.

ABSTRACT:

Background

Genes in populations are in constant flux, being gained through duplication and occasionally retained or, more frequently, lost from the genome. In this study we compare pairs of identifiable gene duplicates generated by small-scale (predominantly single-gene) duplications with those created by a large-scale gene duplication event (whole-genome duplication) in the yeast Saccharomyces cerevisiae.

Results

We find a number of quantifiable differences between these data sets. Whole-genome duplicates tend to exhibit less profound phenotypic effects when deleted, are functionally less divergent, and are associated with a different set of functions than their small-scale duplicate counterparts. At first sight, either of these latter two features could provide a plausible

SUBMITTER: Hakes L 

PROVIDER: S-EPMC2246283 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature