Transcriptional profiling of inductive mesenchyme to identify molecules involved in prostate development and disease.

ABSTRACT:

Background

The mesenchymal compartment plays a key role in organogenesis, and cells within the mesenchyme/stroma are a source of potent molecules that control epithelia during development and tumorigenesis. We used serial analysis of gene expression (SAGE) to profile a key subset of prostatic mesenchyme that regulates prostate development and is enriched for growth-regulatory molecules.

Results

SAGE libraries were constructed from prostatic inductive mesenchyme and from the complete prostatic rudiment (including inductive mesenchyme, epithelium, and smooth muscle). By comparing these two SAGE libraries, we generated a list of 219 transcripts that were enriched or specific to inductive mesenchyme and that may act as mesenchymal regulators of organogenesis and tumorigenesis. W

SUBMITTER: Vanpoucke G 

PROVIDER: S-EPMC2246287 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature