Denoising inferred functional association networks obtained by gene fusion analysis.

ABSTRACT:

Background

Gene fusion detection - also known as the 'Rosetta Stone' method - involves the identification of fused composite genes in a set of reference genomes, which indicates potential interactions between its un-fused counterpart genes in query genomes. The precision of this method typically improves with an ever-increasing number of reference genomes.

Results

In order to explore the usefulness and scope of this approach for protein interaction prediction and generate a high-quality, non-redundant set of interacting pairs of proteins across a wide taxonomic range, we have exhaustively performed gene fusion analysis for 184 genomes using an efficient variant of a previously developed protocol. By analyzing interaction graphs and applying a threshold that limits the maximu

SUBMITTER: Kamburov A 

PROVIDER: S-EPMC2248599 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature