A new perspective on transcriptional system regulation (TSR): towards TSR profiling.

ABSTRACT: It has been hypothesized that the net expression of a gene is determined by the combined effects of various transcriptional system regulators (TSRs). However, characterizing the complexity of regulation of the transcriptome is a major challenge. Principal component analysis on 17,550 heterogeneous human microarray experiments revealed that 50 orthogonal factors (hereafter called TSRs) are able to capture 64% of the variability in expression in a wide range of experimental conditions and tissues. We identified gene clusters controlled in the same direction and show that gene expression can be conceptualized as a process influenced by a fairly limited set of TSRs. Furthermore, TSRs can be linked to biological functions, as we demonstrate a strong relation between TSR-related gene clusters an

SUBMITTER: Fehrmann RS 

PROVIDER: S-EPMC2250855 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature