Protein surface analysis for function annotation in high-throughput structural genomics pipeline.

ABSTRACT: Structural genomics (SG) initiatives are expanding the universe of protein fold space by rapidly determining structures of proteins that were intentionally selected on the basis of low sequence similarity to proteins of known structure. Often these proteins have no associated biochemical or cellular functions. The SG success has resulted in an accelerated deposition of novel structures. In some cases the structural bioinformatics analysis applied to these novel structures has provided specific functional assignment. However, this approach has also uncovered limitations in the functional analysis of uncharacterized proteins using traditional sequence and backbone structure methodologies. A novel method, named pvSOAR (pocket and void Surface of Amino Acid Residues), of comparing the protein

SUBMITTER: Binkowski TA 

PROVIDER: S-EPMC2253251 | biostudies-literature | 2005 Dec

REPOSITORIES: biostudies-literature