Genome-wide screening of copy number alterations and LOH events in renal cell carcinomas and integration with gene expression profile.

ABSTRACT:

Background

Clear cell renal carcinoma (RCC) is the most common and invasive adult renal cancer. For the purpose of identifying RCC biomarkers, we investigated chromosomal regions and individual genes modulated in RCC pathology. We applied the dual strategy of assessing and integrating genomic and transcriptomic data, today considered the most effective approach for understanding genetic mechanisms of cancer and the most sensitive for identifying cancer-related genes.

Results

We performed the first integrated analysis of DNA and RNA profiles of RCC samples using Affymetrix technology. Using 100K SNP mapping arrays, we assembled a genome-wide map of DNA copy number alterations and LOH areas. We thus confirmed the typical genetic signature of RCC but also identified other ampli

SUBMITTER: Cifola I 

PROVIDER: S-EPMC2253555 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature