Membrane-mediated amyloidogenesis and the promotion of oxidative lipid damage by amyloid beta proteins.

ABSTRACT: Evidence of oxidative stress and the accumulation of fibrillar amyloid beta proteins (Abeta) in senile plaques throughout the cerebral cortex are consistent features in the pathology of Alzheimer disease. To define a mechanistic link between these two processes, various aspects of the relationship between oxidative lipid membrane damage and amyloidogenesis were characterized by chemical and physical techniques. Earlier studies of this relationship demonstrated that oxidatively damaged synthetic lipid membranes promoted amyloidogenesis. The studies reported herein specify that 4-hydroxy-2-nonenal (HNE) is produced in both synthetic lipids and human brain lipid extracts by oxidative lipid damage and that it can account for accelerated amyloidogenesis. Abeta promotes the copper-mediated gener

SUBMITTER: Murray IVJ 

PROVIDER: S-EPMC2253689 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature