Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target.

ABSTRACT:

Background

Lung cancer causes approximately 1.2 million deaths per year worldwide, and non-small cell lung cancer (NSCLC) represents 85% of all lung cancers. Understanding the molecular events in non-small cell lung cancer (NSCLC) is essential to improve early diagnosis and treatment for this disease.

Methodology and principal findings

In an attempt to identify novel NSCLC related genes, we performed a genome-wide screening of chromosomal copy number changes affecting gene expression using microarray based comparative genomic hybridization and gene expression arrays on 32 radically resected tumor samples from stage I and II NSCLC patients. An integrative analysis tool was applied to determine whether chromosomal copy number affects gene expression. We identified a deletion o

SUBMITTER: Gallegos Ruiz MI 

PROVIDER: S-EPMC2254495 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature