Effects of telomere length in Drosophila melanogaster on life span, fecundity, and fertility.

ABSTRACT: Chromosome length in Drosophila is maintained by targeted transposition of three non-long terminal repeat retrotransposons, HeT-A, TART, and TAHRE, to the chromosome ends. The length and composition of these retrotransposon arrays can vary significantly between chromosome tips and between fly stocks, but the significance and consequences of these length differences are not understood. A dominant genetic factor, Tel, has been described, which causes a severalfold elongation of the retrotransposon arrays at all telomeres. We used this strain to assess possible affects of extended telomeres on the organism. While we found no effect on life span of the adults, we could demonstrate a correlation between long telomeres and reduced fertility and fecundity in individual females, which is also refl

SUBMITTER: Walter MF 

PROVIDER: S-EPMC2254661 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature