Comparative sequence analysis of acid sensitive/resistance proteins in Escherichia coli and Shigella flexneri.

ABSTRACT: The molecular basis for the survival of bacteria under extreme conditions in which growth is inhibited is a question of great current interest. A preliminary study was carried out to determine residue pattern conservation among the antiporters of enteric bacteria, responsible for extreme acid sensitivity especially in Escherichia coli and Shigella flexneri. Here we found the molecular evidence that proved the relationship between E. coli and S. flexneri. Multiple sequence alignment of the gadC coded acid sensitive antiporter showed many conserved residue patterns at regular intervals at the N-terminal region. It was observed that as the alignment approaches towards the C-terminal, the number of conserved residues decreases, indicating that the N-terminal region of this protein has much act

SUBMITTER: Manikandan S 

PROVIDER: S-EPMC2255067 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature