DLG1 is an anchor for the E3 ligase MARCH2 at sites of cell-cell contact.

ABSTRACT: PDZ domain containing molecular scaffolds plays a central role in organizing synaptic junctions. Observations in Drosophila and mammalian cells have implicated that ubiquitination and endosomal trafficking, of molecular scaffolds are critical to the development and maintenance of cell-cell junctions and cell polarity. To elucidate if there is a connection between these pathways, we applied an integrative genomic strategy, which combined comparative genomics and proteomics with cell biological assays. Given the importance of ubiquitin in regulating endocytic processes, we first identified the subset of E3 ligases with conserved PDZ binding motifs. Among this subset, the MARCH family ubiquitin ligases account for the largest family and MARCH2 has been previously implicated in endosomal traff

SUBMITTER: Cao Z 

PROVIDER: S-EPMC2257480 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature