The P450 oxidoreductase, RedA, controls development beyond the mound stage in Dictyostelium discoideum.

ABSTRACT:

Background

NADPH-cytochrome-P450 oxidoreductase (CPR) is a ubiquitous enzyme that belongs to a family of diflavin oxidoreductases and is required for activity of the microsomal cytochrome-P450 monooxygenase system. CPR gene-disruption experiments have demonstrated that absence of this enzyme causes developmental defects both in mouse and insect.

Results

Annotation of the sequenced genome of D. discoideum revealed the presence of three genes (redA, redB and redC) that encode putative members of the diflavin oxidoreductase protein family. redA transcripts are present during growth and early development but then decline, reaching undetectable levels after the mound stage. redB transcripts are present in the same levels during growth and development while redC expression was det

SUBMITTER: Gonzalez-Kristeller DC 

PROVIDER: S-EPMC2257935 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature