Discovery of genes implicated in whirling disease infection and resistance in rainbow trout using genome-wide expression profiling.

ABSTRACT:

Background

Whirling disease, caused by the pathogen Myxobolus cerebralis, afflicts several salmonid species. Rainbow trout are particularly susceptible and may suffer high mortality rates. The disease is persistent and spreading in hatcheries and natural waters of several countries, including the U.S.A., and the economic losses attributed to whirling disease are substantial. In this study, genome-wide expression profiling using cDNA microarrays was conducted for resistant Hofer and susceptible Trout Lodge rainbow trout strains following pathogen exposure with the primary objective of identifying specific genes implicated in whirling disease resistance.

Results

Several genes were significantly up-regulated in skin following pathogen exposure for both the resistant and suscept

SUBMITTER: Baerwald MR 

PROVIDER: S-EPMC2257940 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature