H-Profile plots for the discovery and exploration of patterns in gene expression data with an application to time course data.

ABSTRACT:

Background

An ever increasing number of techniques are being used to find genes with similar profiles from microarray studies. Visualization of gene expression profiles can aid this process, potentially contributing to the identification of co-regulated genes and gene function as well as network development.

Results

We introduce the h-Profile plot to display gene expression profiles. Thumbnail versions of plots of gene expression profiles are plotted at coordinates such that profiles of similar shape are located in the same sector, with decreasing variance towards the origin. Negatively correlated profiles can easily be identified. A new method for selecting genes with fixed periodicity, but different phase and amplitude is described and used to demonstrate the use of the pl

SUBMITTER: Pittelkow YE 

PROVIDER: S-EPMC2257978 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature