SABERTOOTH: protein structural alignment based on a vectorial structure representation.

ABSTRACT:

Background

The task of computing highly accurate structural alignments of proteins in very short computation time is still challenging. This is partly due to the complexity of protein structures. Therefore, instead of manipulating coordinates directly, matrices of inter-atomic distances, sets of vectors between protein backbone atoms, and other reduced representations are used. These decrease the effort of comparing large sets of coordinates, but protein structural alignment still remains computationally expensive.

Results

We represent the topology of a protein structure through a structural profile that expresses the global effective connectivity of each residue. We have shown recently that this representation allows explicitly expressing the relationship between protein st

SUBMITTER: Teichert F 

PROVIDER: S-EPMC2257979 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature