The determinants of gene order conservation in yeasts.

ABSTRACT:

Background

Why do some groups of physically linked genes stay linked over long evolutionary periods? Although several factors are associated with the formation of gene clusters in eukaryotic genomes, the particular contribution of each feature to clustering maintenance remains unclear.

Results

We quantify the strength of the proposed factors in a yeast lineage. First we identify the magnitude of each variable to determine linkage conservation by using several comparator species at different distances to Saccharomyces cerevisiae. For adjacent gene pairs, in line with null simulations, intergenic distance acts as the strongest covariate. Which of the other covariates appear important depends on the comparator, although high co-expression is related to synteny conservation comm

SUBMITTER: Poyatos JF 

PROVIDER: S-EPMC2258174 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature