Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender.

ABSTRACT:

Background

The structural and functional complexity of the mammalian central nervous system (CNS) is organized and modified by complicated molecular signaling processes that are poorly understood.

Results

We measured transcripts of 16,896 genes in 5 CNS regions from cohorts of young, middle-aged and old male and female mice that had been maintained on either a control diet or a low energy diet known to retard aging. Each CNS region (cerebral cortex, hippocampus, striatum, cerebellum and spinal cord) possessed its own unique transcriptome fingerprint that was independent of age, gender and energy intake. Less than 10% of genes were significantly affected by age, diet or gender, with most of these changes occurring between middle and old age. The transcriptome of the spinal co

SUBMITTER: Xu X 

PROVIDER: S-EPMC2258177 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature