Spore germination in Saccharomyces cerevisiae: global gene expression patterns and cell cycle landmarks.

ABSTRACT:

Background

Spore germination in the yeast Saccharomyces cerevisiae is a process in which non-dividing haploid spores re-enter the mitotic cell cycle and resume vegetative growth. To study the signals and pathways underlying spore germination we examined the global changes in gene expression and followed cell-cycle and germination markers during this process.

Results

We find that the germination process can be divided into two distinct stages. During the first stage, the induced spores respond only to glucose. The transcription program during this stage recapitulates the general transcription response of yeast cells to glucose. Only during the second phase are the cells able to sense and respond to other nutritional components in the environment. Components of the mitotic mac

SUBMITTER: Joseph-Strauss D 

PROVIDER: S-EPMC2258198 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature