Slipins: ancient origin, duplication and diversification of the stomatin protein family.

ABSTRACT:

Background

Stomatin is a membrane protein that was first isolated from human red blood cells. Since then, a number of stomatin-like proteins have been identified in all three domains of life. The conservation among these proteins is remarkable, with bacterial and human homologs sharing 50 % identity. Despite being associated with a variety of diseases such as cancer, kidney failure and anaemia, precise functions of these proteins remain unclear.

Results

We have constructed a comprehensive phylogeny of all 'stomatin-like' sequences that share a 150 amino acid domain. We show these proteins comprise an ancient family that arose early in prokaryotic evolution, and we propose a new nomenclature that reflects their phylogeny, based on the name "slipin" (stomatin-like protein). Wi

SUBMITTER: Green JB 

PROVIDER: S-EPMC2258279 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature