Ontology highlight
ABSTRACT:
SUBMITTER: Cole BK
PROVIDER: S-EPMC2258752 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Cole Banumathi K BK Curto Marcello M Chan Annie W AW McClatchey Andrea I AI
Molecular and cellular biology 20071217 4
Merlin, the product of the NF2 tumor suppressor gene, is closely related to the ERM (ezrin, radixin, moesin) proteins, which provide anchorage between membrane proteins and the underlying cortical cytoskeleton; all four proteins are members of the band 4.1 superfamily. Despite their similarity, the subcellular distributions and functional properties of merlin and the ERM proteins are largely distinct. Upon cell-cell contact merlin prevents internalization of and signaling from the epidermal grow ...[more]