Ontology highlight
ABSTRACT:
SUBMITTER: Bailis JM
PROVIDER: S-EPMC2258774 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Bailis Julie M JM Luche Douglas D DD Hunter Tony T Forsburg Susan L SL
Molecular and cellular biology 20080107 5
The minichromosome maintenance (MCM) complex plays essential, conserved roles throughout DNA synthesis: first, as a component of the prereplication complex at origins and, then, as a helicase associated with replication forks. Here we use fission yeast (Schizosaccharomyces pombe) as a model to demonstrate a role for the MCM complex in protecting replication fork structure and promoting recovery from replication arrest. Loss of MCM function generates lethal double-strand breaks at sites of DNA sy ...[more]