Comparison of the effects of Leishmania major or Leishmania donovani infection on macrophage gene expression.

ABSTRACT: The intracellular parasite Leishmania causes a wide spectrum of human disease, ranging from self-resolving cutaneous lesions to fatal visceral disease, depending on the species of Leishmania involved. The mechanisms by which different Leishmania species cause different pathologies are largely unknown. We have addressed this question by comparing the gene expression profiles of bone marrow-derived macrophages infected with either Leishmania donovani or L. major promastigotes. We found that the two species had very similar effects on macrophage gene expression. Both species caused a small (<2.5-fold) but statistically significant repression of several hundred genes. In addition, both species strongly induced and repressed about 60 genes. Comparing the effects of the two species showed that o

SUBMITTER: Gregory DJ 

PROVIDER: S-EPMC2258831 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature